PRESENTATION NO 001: IBUVEL-PLUS (Ibuprofen BP 200mg + Paracetamol BP 120mg/5ml Suspension)

IBUVEL-PLUS

Ibuprofen BP 200mg + Paracetamol BP 120mg/5ml Suspension

ANTIPYRETIC

• An antipyretic from anti- 'against' and pyretic 'feverish‘, is a substance that reduces fever.
• The body then works to lower the temperature.
• Which results in a reduction in fever.

ANALGESIC

• An analgesic or painkiller is any member of the group of drugs used to achieve analgesia, relief from pain.
• Analgesic drugs act in various ways on the peripheral and central nervous systems.
• They are distinct from anesthetics, which temporarily affect.
• In some instances completely eliminate, sensation.

NSAIDs

• NSAIDs non steroidal anti-inflammatory drugs are a drug class that groups together drugs that provide analgesic (pain-killing) and antipyretic (fever-reducing) effects and in higher doses, anti-inflammatory effects.

Anti-inflammatory

• A drug or substance that reduces inflammation (redness, swelling, and pain) in the body.
• Anti-inflammatory agents block certain substances in the body that cause inflammation.

MECHANISM OF ACTION

ANALGESIC

•   Centrally.
• Inhibition the COX 1-2 (cyclooxygenase) enzymes in the CNS.
•   Periperally.
• Anti inflammatory action.

ANTIPYRETIC

•   Centrally.
• Inhibition the COX 1-2 (cyclooxygenase) enzymes in the CNS.
• Inhibition of interleukin-1

IBUPROFEN Bp 200mg/5ml Suspension

• Ibuprofen is a non steroidal anti-inflammatory drug (NSAID).
• It works by reducing hormones that cause inflammation and pain in the body.
• Your child should start to feel better about 20 to 30 minutes after taking ibuprofen.

Ibuprofen syrup dosages for children

• 3 to 5 months (weighing more than 5kg) 2.5ml Max 3 times in 24 hours.
• 6 to 11 months 2.5ml Max 3 to 4 times in 24 hours.
• 1 to 3 years 5ml Max 3 times in 24 hours.
• 4 to 6 years 7.5ml Max 3 times in 24 hours
• 7 to 9 years 10ml Max 3 times in 24 hours

USES

• Ibuprofen is used to reduce fever and treat pain or inflammation caused by many conditions such as headache, toothache, back pain, arthritis, menstrual cramps, or minor injury.
• It is also used to reduce fever and to relieve minor aches and pain due to the common cold or flu.

SIDE EFFECTS

• Upset stomach, nausea, vomiting, headache, diarrhea, constipation, dizziness, or drowsiness may occur.
• If any of these effects persist or worsen, tell your doctor or pharmacist promptly.
• This medication may raise your blood pressure. Check your blood pressure regularly and tell your doctor if the results are high.
• This drug may rarely cause serious (possibly fatal) liver disease.
•  Get medical help right away if you have any symptoms of liver damage, including: dark urine, persistent nausea/vomiting/loss of appetite, stomach/abdominal pain, yellowing eyes/skin

PRECAUTIONS

• Before taking ibuprofen, tell your doctor or pharmacist if you are allergic to it; or to aspirin or other NSAIDs.
• This product may contain inactive ingredients, which can cause allergic reactions or other problems.
• Kidney problems can sometimes occur with the use of NSAID medications, including ibuprofen.

INTERACTIONS

• This medication may increase the risk of bleeding when taken with other drugs that also may cause bleeding.
• Examples include anti-platelet drugs such as clopidogrel, "blood thinners" such as dabigatran/enoxaparin/warfarin, among others.

OVERDOSE

• Symptoms of overdose may include: severe stomach pain, trouble breathing, extreme drowsiness.
• Paracetamol BP 120mg/5ml Suspension
• Paracetamol, also known as acetaminophen, is a medication used to treat pain and fever.
• It is typically used for mild to moderate pain relief.
• Evidence is mixed for its use to relieve fever in children.
• It is often sold in combination with other medications, such as in many cold medications.

Pediatric Dose for Fever

• Neonates (premature neonates born at least 32 weeks gestational age up to 28 days chronological age): 12.5 mg/kg every 6 hours.
• Infants (29 days to 2 years old): 15 mg/kg every 6 hours.
• 2 to 12 years: 12.5 mg/kg every 4 hours OR 15 mg/kg every 6 hours.

USES

• This drug is used to treat mild to moderate pain (from headaches, menstrual periods, toothaches, backaches, osteoarthritis, or cold/flu aches and pains) and to reduce fever.

SIDE EFFECTS

• A very serious allergic reaction to this drug is rare.
• However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

PRECAUTIONS

• Liquid products, chewable tablets, or dissolving/effervescent tablets may contain sugar or aspartame.
• Caution is advised if you have diabetes, phenylketonuria (PKU), or any other condition that requires you to limit/avoid these substances in your diet.

INTERACTIONS

• A product that may interact with this drug is: ketoconazole.

OVERDOSE

• If someone has overdosed and has serious symptoms such as passing out or trouble breathing.
• Symptoms of overdose may include: nausea, vomiting, loss of appetite, sweating, stomach/abdominal pain, extreme tiredness, yellowing eyes/skin, dark urine.

Manufactured By: interMed

Marketed By: KHAN SEHAT LTD

Presented By: Dr. Anwarullah Ayarkhail