PRESENTATION NO 002 : VEXCEF-C 81.25 SUS Cefixime 50mg & Clavulanate Potassium 31.25mg oral Suspension
VEXCEF- C 81.25 SUS
Cefixime 50mg & Clavulanate Potassium 31.25mg oral Suspension.
- Cefixime, an antibiotic, is a third-generation cephalosporin like ceftriaxone and cefotaxime.
- Cefixime is highly stable in the presence of beta-lactamase enzymes.
- As a result, many organisms resistant to penicillins and some cephalosporins due to the presence of beta-lactamases, may be susceptible to cefixime.
- The antibacterial effect of cefixime results from inhibition of mucopeptide synthesis in the bacterial cell wall.
BACTERIA CELL WALL
MECHANISM OF ACTION
- Like all beta-lactam antibiotics, cefixime binds to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall.
- Causing the inhibition of the third and last stage of bacterial cell wall synthesis.
- Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins.
- Potassium clavulanate is a potassium salt having clavulanate as the counterion.
- Called a suicide, inhibitors, it gets inactivated after binding to the enzyme.
- It acts as a suicide inhibitor of bacterial beta-lactamase enzymes.
- Has only weak antibiotic activity when administered alone.
- Binding with B-lactamase is reversible initially, but becomes covalent later-inhibition increasing with time.
MECHANISM OF ACTION
- Clavunate potassium is an irreversible inhibitor of β-lactamases produced by both gram-positive and gram-negative bacteria.
- Clavuate potassium does not possess any significant antimicrobial action itself.
- Cefixime is extremely stable in the presence of β-lactamase enzymes hence many organisms resistant to penicillins and some cephalosporins may be susceptible to cefixime.
- Cefixime is highly active against gram negative cocci, gram negative bacilli and anaerobes than gram positive cocci and bacilli.
- It is not active against pseudomonas.
Cefixime is used in the treatment of;
- Uncomplicated urinary tract infections.
- Otitis media (inflammation of the ear).
- Acute bronchitis (inflammation of the bronchi).
- Acute exacerbation of chronic bronchitis.
- Uncomplicated gonorrhoea (infections of the cervix, urethra, and rectum).
ADMINISTRATION AND DOSAGE
- Adults (400 mg daily)
- Children (8 mg/kg/day)
- The recommended formulation in children is suspension.
- Weighting more than 50 kg or older than 12 years should be treated with the recommended adult dose of cefixime.
- In the treatment of infections due to Streptococcus pyogenes, the treatment should be for at least 10 days.
- Cefixime is contraindicated in patients with known allergy to the cephalosporin group of antibiotics.
- Cefixime should be used during pregnancy only if clearly needed.
- Dose reduction needed in patients with renal impairment.
- Side effects of cefixime includes:
- Diarrhea that is watery or bloody
- Loose stools.
- Abdominal pain.
- Stomach pain.
- dark colored urine.
- Confusion or weakness.
- Elevated carbamazepine levels have been reported when cefixime is administered concomitantly.
Warfarin and Anticoagulants:
- Increased prothrombin time, with or without clinical bleeding, has been reported when cefixime is administered concomitantly.
- Store at room temperature away from moisture, heat, and light.
- You may also store the oral liquid in the refrigerator.
- Throw away any unused liquid after 14 days.
Manufactured By: VXL
Marketed By: KHAN SEHAT LTD
Presented By: Dr. Anwarullah Ayarkhail