PRESENTATION NO 002 : VEXCEF-C 81.25 SUS Cefixime 50mg & Clavulanate Potassium 31.25mg oral Suspension

VEXCEF- C 81.25 SUS

Cefixime 50mg & Clavulanate Potassium 31.25mg oral Suspension.

CEFIXIME

Cefixime, an antibiotic, is a third-generation cephalosporin like ceftriaxone and cefotaxime.
Cefixime is highly stable in the presence of beta-lactamase enzymes.
As a result, many organisms resistant to penicillins and some cephalosporins due to the presence of beta-lactamases, may be susceptible to cefixime.
The antibacterial effect of cefixime results from inhibition of mucopeptide synthesis in the bacterial cell wall.

BACTERIA CELL WALL

MECHANISM OF ACTION

Like all beta-lactam antibiotics, cefixime binds to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall.
Causing the inhibition of the third and last stage of bacterial cell wall synthesis.
Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins.

POTASSIUM CLAVULANATE

Potassium clavulanate is a potassium salt having clavulanate as the counterion.
Called a suicide, inhibitors, it gets inactivated after binding to the enzyme.
It acts as a suicide inhibitor of bacterial beta-lactamase enzymes.
Has only weak antibiotic activity when administered alone.
Binding with B-lactamase is reversible initially, but becomes covalent later-inhibition increasing with time.

MECHANISM OF ACTION

Clavunate potassium is an irreversible inhibitor of β-lactamases produced by both gram-positive and gram-negative bacteria.
Clavuate potassium does not possess any significant antimicrobial action itself.

ANTIMICROBIAL SPECTRUM

Cefixime is extremely stable in the presence of β-lactamase enzymes hence many organisms resistant to penicillins and some cephalosporins may be susceptible to cefixime.
Cefixime is highly active against gram negative cocci, gram negative bacilli and anaerobes than gram positive cocci and bacilli.
It is not active against pseudomonas.

INDICATIONS

Cefixime is used in the treatment of;

ADMINISTRATION AND DOSAGE

Adults (400 mg daily)
Children (8 mg/kg/day)
The recommended formulation in children is suspension.
Weighting more than 50 kg or older than 12 years should be treated with the recommended adult dose of cefixime.
In the treatment of infections due to Streptococcus pyogenes, the treatment should be for at least 10 days.

CONTRAINDICATIONS

Cefixime is contraindicated in patients with known allergy to the cephalosporin group of antibiotics.
Cefixime should be used during pregnancy only if clearly needed.
Dose reduction needed in patients with renal impairment.

ADVERSE REACTION

INTERACTIONS

Carbamazepine:

Elevated carbamazepine levels have been reported when cefixime is administered concomitantly.

Warfarin and Anticoagulants:

Increased prothrombin time, with or without clinical bleeding, has been reported when cefixime is administered concomitantly.

SPECIAL PRECAUTIONS

Manufactured By: VXL

Marketed By: KHAN SEHAT LTD

Presented By: Dr. Anwarullah Ayarkhail